My main worry is that the bumbling blonde baffoon will introduce the "traffic lights" system which will entail manatory quarantine on return from countries not on the "green" list. This will kill a lot of our normal flight destinations stone dead. And seeing as 99%ish of those likely to suffer the most/clog up the sacred NHS have already been vaccinated, it makes little sense. If the worry is "variants" then no-one will be able to go anywhere, ever. There are always variants, always have been.
The clusterfuckery of the EU vaccination effort is the biggest hurdle and I don't see that being rectified for ~ 3 months.